Principal Statistical Programmer

About the role

ICON Strategic Solutions is seeking a Principal Statistical Programmer to join its sponsor-dedicated team. The role involves analysing clinical trial data and supporting the statistical analysis process so that high-quality results are delivered. It includes developing and validating statistical programs in R, working with biostatisticians and ensuring compliance with regulatory standards.

Key responsibilities

• Develop and validate R programs for statistical analysis and reporting of clinical trial data.
• Lead more than one Statistical Programming team to create, validate and generate statistical outputs, including listings, tables, figures, and CDISC-compliant SDTM and ADaM datasets (including mapping specifications) of low to moderate complexity.
• Collaborate with biostatisticians to define analysis plans and statistical methods for clinical data.
• Perform quality control and validation of statistical outputs, ensuring accuracy, consistency and regulatory compliance.
• Assist in preparing statistical reports, presentations and publications for regulatory submissions and clinical study reporting.
• Contribute to process improvements through efficiencies in programming practices, automation and R-based analytical workflows.
• Support the development, maintenance and enhancement of standardised R programming tools, macros and reporting solutions across studies.

Required profile

• Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences or a related quantitative field.
• 8+ years of experience in statistical programming within clinical research, biotechnology or pharmaceutical environments.
• Strong exposure to leading programming activities for clinical studies.
• Excellent analytical and problem-solving skills, with a keen attention to detail.
• Strong communication skills and ability to work collaboratively in a team.

Required skills

• Strong proficiency in R programming, including development and validation of clinical trial datasets, analyses and reporting outputs.
• Good understanding of CDISC standards, including SDTM and ADaM.
• Familiarity with regulatory requirements and industry guidance on statistical programming and clinical data reporting.

What we offer

• A competitive salary.
• Annual leave entitlements.
• Health insurance options for you and your family.
• Retirement planning offerings.
• Global Employee Assistance Programme (LifeWorks).
• Life assurance.
• Optional country-specific benefits such as childcare vouchers, bike purchase schemes, discounted gym memberships and subsidised travel passes.